Stanford University

Collaborative Research Projects

Gene Editing in the Treatment of SAVI Syndrome

SAVI (Sting Associated Vasculopathy with Onset in Infancy) is a rare and an incurable disorder, with an early age of onset. It is caused by mutations in the STING gene, which is responsible for recognizing invading pathogens. Constitutively active STING, the hallmark of this disease, leads to chronic inflammation in the absence of infections. Currently, there is no definitive therapy for SAVI. The goal of this project is, therefore, to develop an innovative and safe gene therapy approach that is accessible by all SAVI patients.

Ontology of the Medieval Image

This collaborative team-based project focuses on the meaning of images in medieval culture as defined by Scripture, theology, and science; it analyzes iconography though epistemology uncovering the cultural and spiritual framework in which form operates. The French team, led by Isabelle Marchesin, at INHA has developed the platform working on Western medieval art.

Advanced Diagnostics for Astrophysical Beam-Plasma Experiments in the Laboratory

The interaction of highly energetic particles with plasmas plays a major role in the evolution of the universe and gives rise to many astrophysical processes that are not yet fully understood. Our collaboration, consisting of groups from France and the USA, aims at creating these processes within a laboratory, which permits a high degree of control and insight into parameters that are otherwise not accessible.

Population Genetics of Cancer Evolution

Cancer develops when evolutionary forces act on mutated cells. When mutations and natural selection repeat over time, cancerous cell populations grow and spread. The resulting cancer cell population displays extensive genetic and functional heterogeneity within and across tumors. This diversity presents challenges to our understanding of tumor biology and ability to treat cancer, especially because the evolutionary dynamics and variables underlying the heterogeneity are often poorly understood.

The Constitution Of Individuals and Groups in Biological Sciences

Recent biological and biomedical research, especially work on the microbiome, has revived the idea that living things are not “individuals”, but rather collectives. The aim of this interdisciplinary project is to offer a philosophical and scientific examination of the conditions under which something can be said to be an “individual” in the living world – and how, in certain circumstances, individuals function as a single collective, while collectives can function as biological individuals.

Monitoring Therapeutic Cell Treatments Using Novel Nanoprobes

Tissue regeneration through transplantation of therapeutic cells has the potential to revolutionize modern medicine. Therapeutic cells can migrate and differentiate to integrate into their biological environment. Despite great promises from preclinical applications, there are many open questions regarding successful approaches for tissue regeneration and safe applications of therapeutic cells in patients. Labeling therapeutic cells with imaging probes and tracking them with imaging technologies can answer these questions.

The Multiplicity Turn: Theories of Identity From Poetry to Mathematics

In the last century, major breakthroughs in our understanding of ‘identity’ have changed the way that we think about ourselves and the world around us. In the Humanities, fields such as Race and Ethnicity Studies, Gender Studies, History, and Literary Studies have taught us to think of who we are and how we identify ourselves from an intersectional, multicultural, and interspecies viewpoint.