Stanford University

Collaborative Research Projects

Improving Perioperative Care for Children Receiving Solid Organ Transplantation

Pediatric liver transplantation is a very challenging surgical procedure that saves lives for children that are born or develop severe liver disease. The pediatric liver transplant program at Stanford, is one of the largest program in United States with excellent outcomes for both graft and patient survival. Similarly, L’hospital Necker Enfants malades in Paris is one of the largest centers in Europe with great outcomes.

AI-based Computational Modeling Tools with Applications to Psychiatric Disorders

The ability to orient attention to dynamic changes in the environment is an essential cognitive skill. Aberrations in this ability are often observed in many psychiatric and neurological disorders, but the underlying neurophysiological mechanisms are not well understood. This project focuses on the development of novel biologically inspired artificial intelligence models for characterizing human brain function and dysfunction, with a special focus on improving our understanding of these mechanisms.

Mapping the Early Cape

This project will digitally map Le Vaillant’s journey from the account of his journey into the interior of the Cape of Good Hope (1781-83). The Voyage de M. le Vaillant dans l’Interieur de l’Afrique par le Cap de Bonne-Espérance (1790) stands out for its detailed ethnography of the amaXhosa and Khoe people; for its natural history; and for its cartography. The text offers unique insights into South Africa’s early colonial period, and the natural history arising from this ‘first safari’ is directly reflected in French museum collections.

Gene Editing in the Treatment of SAVI Syndrome

SAVI (Sting Associated Vasculopathy with Onset in Infancy) is a rare and an incurable disorder, with an early age of onset. It is caused by mutations in the STING gene, which is responsible for recognizing invading pathogens. Constitutively active STING, the hallmark of this disease, leads to chronic inflammation in the absence of infections. Currently, there is no definitive therapy for SAVI. The goal of this project is, therefore, to develop an innovative and safe gene therapy approach that is accessible by all SAVI patients.

Ontology of the Medieval Image

This collaborative team-based project focuses on the meaning of images in medieval culture as defined by Scripture, theology, and science; it analyzes iconography though epistemology uncovering the cultural and spiritual framework in which form operates. The French team, led by Isabelle Marchesin, at INHA has developed the platform working on Western medieval art.

Advanced Diagnostics for Astrophysical Beam-Plasma Experiments in the Laboratory

The interaction of highly energetic particles with plasmas plays a major role in the evolution of the universe and gives rise to many astrophysical processes that are not yet fully understood. Our collaboration, consisting of groups from France and the USA, aims at creating these processes within a laboratory, which permits a high degree of control and insight into parameters that are otherwise not accessible.

Population Genetics of Cancer Evolution

Cancer develops when evolutionary forces act on mutated cells. When mutations and natural selection repeat over time, cancerous cell populations grow and spread. The resulting cancer cell population displays extensive genetic and functional heterogeneity within and across tumors. This diversity presents challenges to our understanding of tumor biology and ability to treat cancer, especially because the evolutionary dynamics and variables underlying the heterogeneity are often poorly understood.

The Constitution of Individuals and Groups in the Biological Sciences: Implications of an Ecological Framework for Understanding Cancer

Recent biological and biomedical research has featured the idea that living things are not “individuals” but collectives.  Gordon and Pradeu examine this question, combining the perspectives of a biologist who studies collective behavior in ant colonies and other natural systems and a philosopher of science who studies the immune system and the microbiome.  They offer a philosophical and scientific examination of the conditions under which something can be said to be an “individual” in the living world, and how, in certain circumstances, individuals